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Use caution with: obstructed bile duct, impaired liver function, and pancreatic disease. The effectiveness of orlistat in promoting weight loss is definite but modest. Packaging of orlistat (Xenical) 120 mg capsules, as sold in Canada. However, potential side effects of Orlistat, such as inhibition of other cellular off-targets or poor bioavailability, might hamper its application as an effective antitumor agent. The incidence of acute liver injury was higher in the periods both immediately before and immediately after the start of orlistat treatment. Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. Absorption of fat-soluble vitamins and other fat-soluble nutrients is inhibited by the use of orlistat. Orlistat is a drug designed to treat obesity.
Orlistat was also recently found to inhibit the thioesterase domain of fatty acid synthase (FAS), an enzyme involved in the proliferation of cancer cells but not normal cells. This study showed no evidence of an increased risk of liver injury during treatment. The primary route of elimination is through the feces. Benefits aside, however, orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects ), which can include steatorrhea (oily, loose stools). Orlistat is used for the treatment of obesity. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. The amount of weight loss achieved with orlistat varies. Orlistat also show potential activities mycobacteria and Trypanosoma brucei parasite (See further reading). This suggests that the observed increased risks of liver injury linked to the start of treatment may reflect changes in health status associated with the decision to begin treatment rather than any causal effect of the drug.
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